Dr. Brandon Kim has been awarded a $447K NIH R15 grant to study impairment of the cerebral vasculature during bacterial meningitis. Bacterial meningitis is a serious life-threatening infection of the central nervous system that occurs when bacteria are able to cross the highly specialized cerebral vasculature and enter the brain. The cells that comprise the cerebral vasculature are collectively known as the blood-brain barrier and possess unique properties that ensure proper brain homeostasis while also restricting toxins and pathogens. Group […]
Dr. Brandon Kim awarded $447K NIH R15 grant to study impairment of the cerebral vasculature during bacterial meningitis
![Effect of GBS infection on the efflux transporter P-glycoprotein (P-gp) in the brains of mice. Uninfected animals show expected P-gp expression co-localized with the blood vessel marker lectin (top). GBS infection results in a loss of P-gp in the cerebral vasculature where little to no P-gp is detected infected mouse brain (bottom).](https://bsc.ua.edu/wp-content/uploads/2023/09/image005.png)