Lukasz Ciesla

Lukasz  Ciesla

Assistant Professor


Education

  • Ph.D., Pharmaceutical Sciences, Medical University of Lublin, Poland, 2011
  • Postdoctoral work: Department of Plant Biochemistry and Crop Quality, Institute of Soil Science and Plant Cultivation, Poland; Medical University of Lublin; Laboratory of Clinical Investigation, National Institute on Aging in Baltimore.

Research Interests

  • Herbal medicines
  • Secondary plant metabolism
  • Isolation and structure elucidation of secondary plant metabolites
  • Drug discovery programs from natural matrices
  • Novel therapies for prevention and/or treatment of neurodegenerative diseases

Publications

Ł. Cieśla and R. Moaddel. Modern analytical techniques for the identification of bioactive compounds from natural products, Nat. Prod. Rep. 33 (2016) 1131-1145.

Ł. Cieśla, M.Okine, A.Rosenberg, K.S.S.Dossou, L.Toll, I.W.Wainer, R.Moaddel. Development and characterization of an α3β4α5 nicotinic receptor cellular membrane affinity chromatography column and its application for on line screening of plant extracts, J. Chromatogr. A 1431 (2016)138-144.

González-Mariscal, S. M. Krzysik-Walker, M. E. Doyle, Q.R. Liu, R. Cimbro, S. Santa-Cruz Calvo, S. Ghosh, Ł. Cieśla, R. Moaddel, O. D. Carlson, R. P. Witek, J. F. O’Connell, J. M. Egan, A peripheral CB1 receptor isoform differentially regulates adenylyl cyclase activity in pancreatic β-cells and hepatocytes, Sci. Rep. 6 Article number: 33302 (2016).

Ł. Cieśla, K. Wojtunik, A. Oniszczuk, M. Waksmundzka-Hajnos. Antioxidant synergism and antagonism between selected monoterpenes using 2,2-diphenyl-1-picrylhydrazyl method, Flav. Frag. J. 31 (2016) 412-419.

K. Wojtunik-Kulesza, K. Targowska-Duda, K. Klimek, G. Ginalska, K. Jóźwiak, M. Waksmundzka-Hajnos, Ł. Cieśla, Volatile terpenoids as potential drug leads in Alzheimer’s disease, Open Chemistry, accepted on 04.06.2017.

Ł. Cieśla, M. Waksmundzka-Hajnos, K. Wojtunik, M. Hajnos, Thin-layer chromatography coupled with biological detection to screen natural mixtures for potential drug leads. Phytochemistry Letters 11 (2015) 445-454.

Kowalska, Ł. Pecio, Ł. Cieśla, W. Oleszek, A. Stochmal. Isolation, chemical and antioxidant characterization of phenolics from Triticum aestivum L. aerial parts, J. Agric. Food Chem. 62 (2014), 11200–11208.

Wojtunik, Ł. Cieśla, M. Waksmundzka-Hajnos. Model studies on the antioxidant activity of common terpenoid constituents of essential oils by means of the 2,2-diphenyl-1-picrylhydrazyl method, J. Agric. Food Chem. 62 (2014) 9088–9094.

Och, A. Och, Ł. Cieśla, T. Kubrak, Ł. Pecio, A. Stochmal, J. Kocki, A. Bogucka-Kocka. Study of cytotoxic activity, podophyllotoxin and deoxypodophyllotoxin content in selected Juniperus species cultivated in Poland, Pharm. Biol. 53 (2014) 831-837.

Kowalska, D. Jędrejek, Ł. Cieśla, Ł. Pecio, S. Piacente, M. Mosullo, W. Oleszek, A. Stochmal, Isolation, chemical and antioxidant characterization of phenolics from Trifolium scabrum L. aerial parts, J. Agric. Food Chem. 61 (2013) 4417-4423.

Ł. Cieśla, J. Kryszeń, A. Stochmal, W. Oleszek, M. Waksmundzka-Hajnos, Approach to develop a standardized TLC-DPPH test for assessing free radical scavenging properties of selected phenolic compounds, J. Pharm. Biomed. Anal. 70 (2012) 126-135.

Ł. Cieśla, I. Kowalska, W. Oleszek, A. Stochmal, Free radical scavenging activities of polyphenolic compounds isolated from Medicago sativa and Medicago truncatula assessed by means of thin-layer chromatography DPPH˙ rapid test, Phytochem. Anal. 24 (2013) 47-52.

Ł. Cieśla, J. Kryszeń, A. Stochmal, W. Oleszek, M. Waksmundzka-Hajnos, Low-temperature thin-layer chromatography preliminary bioautographic tests for detection of  free radical scavengers and acetylcholinesterase inhibitors in volatile samples, J. Planar Chromatogr. 25 (2012) 225-231.

Ł. Cieśla, Thin-layer chromatography with biodetection for the search of new potential drugs to treat neurodegenerative diseases – state of the art and future perspectives, Med. Chem. 8 (2012) 102-111.

Olech, Ł. Komsta, R. Nowak, Ł. Cieśla, M. Waksmundzka-Hajnos, Investigation of antiradical activity of plant material by thin-layer chromatography with image processing. Food Chem 132 (2012) 549-553.

Ł. Komsta, Ł. Cieśla, A. Bogucka-Kocka, A. Józefczyk, J. Kryszeń, M. Waksmundzka-Hajnos, The start-to-end chemometric processing of 2D thin-layer videoscans, J. Chromatogr. A 1218 (2011) 2820-2825.

Ł. Cieśla, D. Staszek, M. Hajnos, T. Kowalska, M. Waksmundzka-Hajnos, Development of chromatographic and free radical scavenging activity fingerprints by thin-layer chromatography for selected Salvia species, Phytochem. Anal. 22 (2011) 59-65.

Ł. Cieśla, A. Bogucka-Kocka, M. Hajnos, A. Petruczynik, M. Waksmundzka-Hajnos, Two-dimensional thin-layer chromatography with adsorbent gradient as a method of chromatographic fingerprinting of furanocoumarins for distinguishing selected varieties and forms of Heracleum spp., J. Chromatogr. A 1207 (2008) 160-168.

Ł. Cieśla, M. Waksmundzka-Hajnos, Two-dimensional thin-layer chromatography in the analysis of secondary plant metabolites, J. Chromatogr. A 1216 (2009) 1035-1052.

Books 

Co-editorship of the book High Performance Liquid Chromatography in Phytochemical Analysis, CRC Press/Taylor & Francis, 2nd Edition, in preparation.

Book Chapters

Ł. Cieśla, R. Moaddel, Bioaffinity chromatography for the identification of bioactive components in High Performance Liquid Chromatography in Phytochemical Analysis, CRC Press/Taylor & Francis, 2nd Edition, in preparation.

Ł. Cieśla, High resolution mass spectrometry (tandem mass spectrometry) – new trends and limitations in analysis of xenobiotics and unknown compounds in food, environmental and biological samples in ‘Determination of Target Xenobiotics and Unknown Compound Residues in Food and Environmental Samples’, in preparation.

Ł. Cieśla, M. Waksmundzka-Hajnos, J. Sherma, Thin Layer Chromatography, Ewing’s Instrumentation Handbook, 4th edition, in preparation.

Załuski, Ł. Cieśla, Z. Janeczko, The Structure-Activity Relationships of Plant Secondary Metabolites with Antimicrobial, Free Radical Scavenging and Inhibitory Activity towards Selected Enzymes in Studies in Natural Products Chemistry (Bioactive Natural Products), Atta-Ur-Rahman (Ed.) 2015 Elsevier, Amsterdam, Netherlands, volume 45, chapter 7, pp. 218-249.

Waksmundzka-Hajnos, M. Hawrył, Ł. Cieśla, Analysis of plant materials in Instrumental Thin-Layer Chromatography, C.F. Poole (Ed.) 2014 Elsevier, Amsterdam, Netherlands.

Ł. Cieśla, I. Kowalska, Detection and identification in TLC drug analysis, , Ł. Komsta, M. Waksmundzka-Hajnos, J. Sherma (Ed.) 2013 CRC Press, Boca Raton, USA.

Ł. Cieśla, TLC of Alzheimer’s disease medicines – TLC in drug analysis, Ł. Komsta, M. Waksmundzka-Hajnos, J. Sherma (Ed.) 2013 CRC Press, Boca Raton, USA.

Ł. Cieśla, HPLC of Carotenoids – High-Performance Liquid Chromatography in Phytochemical Analysis, M. Waksmundzka-Hajnos, J. Sherma (Ed.) 2010 CRC Press, Boca Raton, USA.

Ł. Cieśla, M. Waksmundzka-Hajnos – Separation of ionic analytes: reversed-phase, ion pair, ion-exchange, ion-exclusion HPLC in High-Performance Liquid Chromatography in Phytochemical Analysis, M. Waksmundzka-Hajnos, J. Sherma (Ed.) 2010 CRC Press, Boca Raton, USA.